In March 2000, President William Clinton signed Executive Order 13,147, establishing the White House Commission on Complementary and Alternative Medicine, to develop public policy proposals geared toward maximizing “the benefits to Americans of complementary and alternative medicine.” Disconcertingly, the Commission's charge presumed the safety and efficacy of complementary and alternative medicine. In so doing, it placed the proverbial cart before the horse by setting the Commission on a mission to “address education and training of health care practitioners in CAM; [coordinate] (...) research to increase knowledge about CAM products; [provide] reliable and useful information on CAM to health care professions, and [provide] guidance on the appropriate access to and delivery of CAM.”The Commission's final report, issued in March 2002, similarly skirts the fundamental question of whether evidence exists that CAM interventions are safe or offer sufficient benefit to justify their proliferation. (shrink)

In March 2000, President William Clinton signed Executive Order 13,147, establishing the White House Commission on Complementary and Alternative Medicine, to develop public policy proposals geared toward maximizing “the benefits to Americans of complementary and alternative medicine.” Disconcertingly, the Commission's charge presumed the safety and efficacy of complementary and alternative medicine. In so doing, it placed the proverbial cart before the horse by setting the Commission on a mission to “address education and training of health care practitioners in CAM; [coordinate] (...) research to increase knowledge about CAM products; [provide] reliable and useful information on CAM to health care professions, and [provide] guidance on the appropriate access to and delivery of CAM.”The Commission's final report, issued in March 2002, similarly skirts the fundamental question of whether evidence exists that CAM interventions are safe or offer sufficient benefit to justify their proliferation. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:John Locke and the Eighteenth-Century Divine by Alan P.F. SellKathy SquadritoAlan P.F. Sell. John Locke and the Eighteenth-Century Divine. Cardiff: University of Wales Press, 1997. Pp. xi + 444. Cloth, $75.00.Professor Sell’s goal is to discern the impact of Locke’s thought upon the later divines; Sell’s scope is the seventeenth century through the nineteenth century. Most of the text is a detailed descriptive account of various scholars’ reactions (...) to Locke’s epistemology, metaphysics, and views concerning religion. Sell focuses on the question of the relative authority of scripture, reason and revelation. He contends that Locke’s epistemological and political positions are intimately bound up with his Christian faith, that as a conservative empiricist, Locke is “much more the rationalist than he has sometimes been painted” (48). The important question bequeathed by Locke to Christian apologetics is: “can the epistemological starting point be redeemed for Christian apologetic use or is it not viable at all?” (12). Sell addresses this question throughout the following chapters: “Ideas, Knowledge and Truth”; “Reason, Revelation, Faith and Scripture”; “Morality and Liberty”; “Toleration and Government”; and “Christian Doctrine”.Sell notes Locke’s roots in Calvinism, his appreciation of Arminian doctrine and his friendship with a number of prominent Latitudinarians. He argues that most criticisms of Locke’s Reasonableness of Christianity are misguided. During the seventeenth and eighteenth centuries Locke was charged with scepticism, deism, Socinianism and materialism. Sell presents the objections of numerous scholars, notably Bishop Stillingfleet, William Carroll, John Norris, Richard Bentley, Henry Lee, Richard Price, Bishop Berkeley, and Samuel Johnson. He also covers the views of Locke’s defenders, including Anthony Collins, Catharine Cockburn and Samuel Bold.The reader might be disappointed with Sell’s short presentation of an inordinate number of Lockean critics; there is little analysis or discussion of the merits of the particular objections cited. He does offer an analysis of the general charges against Locke, but rarely quotes Locke sufficiently to justify his conclusion that Locke was not a deist, sceptic, or materialist. Sell simply takes Locke’s word for it. This book is best taken as an excellent reference guide.Sell contends that in spite of Locke’s friendship with deists such as Collins, Locke’s Reasonableness of the Christian Religion was written to dissolve the deist prejudice against Christianity. He dismisses the charge of deism because: (1) Locke argues for revelation and against natural religion, (2) Locke’s God possesses the traditional attributes assigned to him (power, omniscience, providence), (3) Locke grounds morality not exclusively in natural law, as did deists, but in the gospel, (4) the anti-materialist thrust of Book IV, Chapter X of the Essay, and (5) Locke’s argument that there can be truths of revelation which are above reason. Sell concludes that the “main problem posed to Locke by the deists was that of guilt by association” (209), in other words Locke’s work was misused for political reasons.Sell considers the charge of Socinianism more serious than that of deism. Socinianism is defined by its denial of the Trinity, and by the claims that there cannot be an innate idea of God, that there is no original corruption deriving from Adam, that the wicked will not suffer eternal torments, and that some bodies are not raised at general resurrection. Despite Locke’s agreement with most Socinian claims, Sell claims that [End Page 631] Locke cannot be pinned down on the issue of the Trinity. There is no question, he says, that “the Locke of 1662 affirmed both the doctrine of the Trinity and the human divine nature of Christ, whilst recognizing that the human mind could not explain how these things could be so; there is no question that especially from the 1690’s onwards he was actively reviewing the matter; there is no hard evidence that he ever repudiated the doctrine.” (214)According to Stillingfleet, Locke’s sensationalism and his proposal that matter might be capable of thought undermine Christian faith. Sell does not find this charge convincing. He defends Locke’s distinction between “the man” and “the person,” stressing that Locke claims a high degree of probability that the... (shrink)

Readers eager to acquire a basic familiarity with the history of philosophy but intimidated by the task will find in A Passion for Wisdom a lively, accessible, and highly enjoyable tour of the world's great ideas. Here, Robert Solomon and Kathleen Higgins tell the story of philosophy's development with great clarity and refreshing wit. The authors begin with the most ancient religious beliefs of the east and west and bring us right up to the feminist and multicultural philosophies of (...) the present. Along the way, they highlight major philosophers, from Plato and the Buddha to William James and Simone de Beauvoir, and explore major categories, from metaphysics and ethics to politics and logic. The book is enlivened as well by telling anecdotes and sparkling quotations. Among many memorable observations, we're treated to Thomas Hobbes' assessment that life is "nasty, brutish, and short" and Hegel's description of Napoleon as "world history on horseback." Engaging, comprehensive, and delightfully written, A Passion for Wisdom is a splendid introduction to an intellectual tradition that reaches back over three thousand years. (shrink)

When the ancient Greek philosopher, Pythagoras, was asked if he was a wise man, he humbly replied "No, I am only a lover of wisdom." This love of wisdom has been central to the philosophical enterprise for thousands of years, inspiring some of the most dazzling and daring achievements of the human intellect and providing the very basis for how we understand the world. Now, readers eager to acquire a basic familiarity with the history of philosophy but intimidated by the (...) task will find in A Passion for Wisdom: Philosophy Through the Ages, a lively, accessible, and highly enjoyable tour of the world's great ideas. Without simplifying their subject, editors Robert Solomon and Kathleen Higgins tell the story of philosophy's development with great clarity and refreshing wit. The brevity of their study, in fact, allows readers to see more clearly the connections and divergences between philosophers, as well as the way ideas change, reappear, and evolve over time. The authors begin with the most ancient religious beliefs and bring us right up to the feminist and multicultural philosophies of the present. Along the way, major philosophers are highlighted, from Plato and Aquinas to William James and Simone deBeauvoir, and major categories explored, from metaphysics and ethics to politics and logic. We also see the evolution of enduring ideas--how, for example, the value of subjective experience is treated in Augustine, Luther, Descartes, and Kirkegaard, how the idea of dynamic change appears in the work of Heraclitus, Darwin, Hegel, and Nietzsche, and how the recurring dichotomies between faith and reason, belief and skepticism, mysticism and empiricism occupy philosophers from one generation to the next. The authors make clear the many ways philosophers have argued with, borrowed from, and built on each other's ideas throughout the ages. We see Francis Bacon rejecting Aristotelian dogma, the impact of Buddhism on Schopenhauer, and the influence of Hume and Rousseau on the monumental philosophy of Imanuel Kant. The book is enlivened as well by telling anecdotes and sparkling quotations. We're treated to Thomas Hobbes' assessment--"Life is nasty, brutish, and short," Hegel's description of Napoleon as "world history on horseback," Schopenhauer's assertion that Art allows us a "Sabbath from the penal servitude of willing," and many other memorable and provocative observations. Accessible, comprehensive, and delightfully written, A Passion for Wisdom is a splendid introduction to an intellectual tradition that reaches back over three thousand years. More than that, it is a much-needed reminder for the present of the power inherent in humanity's wonder before the world. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

Tulving posited that the capacity to remember is one facet of a more general capacity—autonoetic consciousness. Autonoetic consciousness was proposed to underlie the ability for “mental time travel” both into the past and into the future to envision potential future episodes . The current study examines whether individual differences can predict autonoetic experience. Specifically, the Zimbardo Time Perspective Inventory was administered to 133 undergraduate students, who also rated phenomenological experiences accompanying autobiographical remembering and episodic future thinking. Scores on two of (...) the five subscales of the ZTPI predicted the degree to which people reported feelings of mentally traveling backward in time and the degree to which they reported re- or pre-experiencing the event, but not ten other rated properties less related to autonoetic consciousness. (shrink)

Exploring the connections between autobiography and postmodernism, this book addresses self-representation in a variety of literatures - Native American, British, Chicana, immigrant, and lesbian, among others - in genres as diverse as poetry, naming, confession, photography, and the manifesto. The essays examine how different writers respond to the culturally specific pressures of genre, how these constraints are negotiated, and what self-representation reveals about the politics of identity.

ABSTRACT Throughout the early modern period, the most widely read astronomical textbooks were Johannes de Sacrobosco's De sphaera and the Theorica planetarum, ultimately in the new form introduced by Georg Peurbach. This essay argues that the images in these texts were intended to develop an “intelligent eye.” Students were trained to transform representations of specific heavenly phenomena into moving mental images of the structure of the cosmos. Only by learning the techniques of mental visualization and manipulation could the student “see” (...) in the mind's eye the structure and motions of the cosmos. While anyone could look up at the heavens, only those who had acquired the intelligent eye could comprehend the divinely created order of the universe. Further, the essay demonstrates that the visual program of the Sphaera and Theorica texts played a significant and hitherto unrecognized role in later scientific work. Copernicus, Galileo, and Kepler all utilized the same types of images in their own texts to explicate their ideas about the cosmos. (shrink)

ABSTRACT Throughout the early modern period, the most widely read astronomical textbooks were Johannes de Sacrobosco's De sphaera and the Theorica planetarum, ultimately in the new form introduced by Georg Peurbach. This essay argues that the images in these texts were intended to develop an “intelligent eye.” Students were trained to transform representations of specific heavenly phenomena into moving mental images of the structure of the cosmos. Only by learning the techniques of mental visualization and manipulation could the student “see” (...) in the mind's eye the structure and motions of the cosmos. While anyone could look up at the heavens, only those who had acquired the intelligent eye could comprehend the divinely created order of the universe. Further, the essay demonstrates that the visual program of the Sphaera and Theorica texts played a significant and hitherto unrecognized role in later scientific work. Copernicus, Galileo, and Kepler all utilized the same types of images in their own texts to explicate their ideas about the cosmos. (shrink)

In this article I show that although biological and neuropsychological factors enable and constrain the construction of music, culture is implicated on every level at which we can indicate an emotion-music connection. Nevertheless, music encourages an affective sense of human affiliation and security, facilitating feelings of transcultural solidarity.

BackgroundCommunity engagement in research has gained momentum as an approach to improving research, to helping ensure that community concerns are taken into account, and to informing ethical decision-making when research is conducted in contexts of vulnerability. However, guidelines and scholarship regarding community engagement are arguably unsettled, making it difficult to implement and evaluate.DiscussionWe describe normative guidelines on community engagement that have been offered by national and international bodies in the context of HIV-related research, which set the stage for similar work (...) in other health related research. Next, we review the scholarly literature regarding community engagement, outlining the diverse ethical goals ascribed to it. We then discuss practical guidelines that have been issued regarding community engagement. There is a lack of consensus regarding the ethical goals and approaches for community engagement, and an associated lack of indicators and metrics for evaluating success in achieving stated goals. To address these gaps we outline a framework for developing indicators for evaluating the contribution of community engagement to ethical goals in health research.SummaryThere is a critical need to enhance efforts in evaluating community engagement to ensure that the work on the ground reflects the intentions expressed in the guidelines, and to investigate the contribution of specific community engagement practices for making research responsive to community needs and concerns. Evaluation mechanisms should be built into community engagement practices to guide best practices in community engagement and their replication across diverse health research settings. (shrink)

A fundamental aspect of human beings is that they learn. The process of learning and what is learned are impacted by a number of factors, both cognitive and social; that is, humans are boundedly rational. Cognitive and social limitations interact, making it difficult to reason about how to provide information to impact what humans know, believe, and do. Herein, we use a multi‐agent dynamic‐network simulation system, Construct, to conduct such reasoning. In particular, we ask, What media should be used to (...) provide information to most impact what people know, believe, and do, given diverse social structures? All simulated agents are boundedly rational both at the cognitive and social level, and so are subject to factors such as literacy, education, and the breadth of their social network. We find that there is no one most effective intervention; rather, to be effective, messages and the media used to spread the message need to be selected for the population being addressed. Typically, a multimedia campaign is critical. (shrink)

The market changes sweeping the U.S. health care industry have a distinctive impact on communities that rely on religiously affiliated health care providers. When a sectarian sponsor subsumes multiple providers, its assertion of religious beliefs can preclude the provision of certain health care services to the entire community. In addition, the sectarian provider's refusal to offer certain services may violate state certificates of need, licensing, Medicaid managed care, or even professional liability law. This situation challenges both the provider and the (...) state: the provider seeks adherence to religious law, and the state seeks compliance with its law and citizens access to health care.I propose that the state attempt to ameliorate tensions between civil and religious laws through negotiated accomodation. This concept encourages the sectarian institution to reassess its mission in the current market and to identify alternative avenues of health care delivery that will preserve patients' access to care without excessively diluting religious identity or beliefs. (shrink)

The market changes sweeping the U.S. health care industry have a distinctive impact on communities that rely on religiously affiliated health care providers. When a sectarian sponsor subsumes multiple providers, its assertion of religious beliefs can preclude the provision of certain health care services to the entire community. In addition, the sectarian provider's refusal to offer certain services may violate state certificates of need, licensing, Medicaid managed care, or even professional liability law. This situation challenges both the provider and the (...) state: the provider seeks adherence to religious law, and the state seeks compliance with its law and citizens access to health care.I propose that the state attempt to ameliorate tensions between civil and religious laws through negotiated accomodation. This concept encourages the sectarian institution to reassess its mission in the current market and to identify alternative avenues of health care delivery that will preserve patients' access to care without excessively diluting religious identity or beliefs. (shrink)

This article examines how women members of contemporary U.S. racist groups reconcile the male-oriented agendas of organized racism with understandings of themselves and their gendered self-interests. Using life history narratives and in-depth interviews, the author examines how women racial activists construct self-understandings that fit agendas of the racist movement and how they reshape understandings of movement goals to fit their own beliefs and life experiences. This analysis situates the political actions of women racists in rational, if deplorable, understandings of self (...) and society. (shrink)

This book is the first full-scale edition of the so-called Liber spectaculorum by Martial. A comprehensive introduction addresses the role of epigram in commemorating monuments and occasions, the connection between spectacle and imperial panegyric in Martial's oeuvre, characteristics of the collection, possible circumstances of composition and 'publication', transmission of the text, and related issues. Each epigram is followed by an apparatus criticus, an English translation, and a detailed commentary on linguistic, literary, and historical matters, adducing extensive evidence from epigraphy and (...) art as well as literary sources. The book is accompanied by four concordances, five tables, two maps, 30 plates, and an appendix. (shrink)

Whether they realize it or not, most stakeholders in the debate about using animals for research agree on the common goal of seeking an end to research that causes animals harm. The central issues in the controversy are about how much effort should be devoted to that goal and when we might reasonably expect to achieve it. Some progress has already been made: The number of animals used for research is about half what it was in the 1970s, and biomedical (...) research has reached the point where we can reasonably begin to envision a time when it could advance without causing harm to animals. With some effort and aggressive development of new biomedical research technologies, full replacement of animals in harmful research is within our grasp. The goal will not be reached all at once, however, and phasing out invasive research on all nonhuman primates should be the priority. (shrink)

Childhood sexual, physical, or emotional abuse can result in splitting many aspects of the emotional and rational sides of a person. Commonly the emotions become confused and difficult to name, and the rational side dominates as a survival mechanism. This can be exacerbated by simplistic teaching that suggests people need to choose to act in certain ways and ignore their emotions. Examples of biblical lament provide helpful models of integration between the rational and emotional sides, encouraging the naming of negative (...) emotions before God, turning to God rather than away from God to an abuser. A realistic grasp of forgiveness and repentance enables wounded people to find healing as they work towards integrating emotions, rationality, and spiritual formation. (shrink)

One of the reasons for the disappearance of beauty in the artistic ideology of the late twentieth century has been the seeming similarity of beauty to certain kinds of kitsch. Beauty has also been associated with flawlessness and with glamour. I will content that the flawless and the glamorous are actually categories of kitsch, and that the dominance of these images in marketing has contributed to our societal tendency to confuse them with beauty. The quests for flawlessness and glamour are (...) both self-sabotaging, a premise on which the marketing of beauty depends. These false paradigms of beauty have ob cured the fact that human beauty manifests an ideal of balance and health that is neither self-conscious nor a consequence of deliberate effort. I will defend the relevance of this ideal to beauty to our personal and cultural well-being. (shrink)

Book reviewed in this article: Death and Dignity: Making Choices and Taking Charge. By Timothy E. Quill.

During the past few years significant progress has been made in our understanding of the structure and function of the proteins involved in eukaryotic DNA replication. Data from several laboratories suggest that, in contrast to prokaryotic DNA replication, two distinct DNA polymerases are required for eukaryotic DNA replication, i.e. DNA polymerase delta for the synthesis of the leading strand and DNA polymerase alpha for the lagging strand. Several accessory proteins analogous to prokaryotic replication factors have been identified and some of (...) these are specific for pol delta whereas others affect both DNA replicases. The replicases and their accessory proteins appear to be highly conserved in eukaryotes, as homologous proteins have been found in species ranging from humans to yeast. (shrink)

This essay applies the issues raised by Althaus-Reid to feminist theology, the Religious Left, and public policy in the US. Against many feminist theologies, it argues that an idealistic theology of eros has led feminist theologians to ask too much of sex. Particularly in the public arena, sexual ethics should be minimalist, focussing on the prevention of serious public harm and the promotion of sexual and reproductive freedom. The Religious Left, whether under the influence of old Christian anti-sexualism or the (...) newer theologies of eros, has failed to stand for sexual freedom as such and has instead sought to bring abortion rights and gay rights into the realm of sexual decency. The most pernicious example is the Religious Left's tacit acceptance of new public policies that deny women, in particular poor black women, sexual and reproductive freedom outside patriarchal marriage. (shrink)

Feminist scholars argue that women generally gain political rights followed by civil and social rights. However, this argument is based on data from North America and Western Europe, and few scholars, if any, have examined the progression of these rights within countries currently undergoing transitions to democracy in different parts of the world. Through in-depth interviews with members of women's organizations in Ghana, the author extends this literature. The findings both contradict and support the prior feminist argument. They indicate that (...) prior to democratization, women focused primarily on social rights to improve their economic well-being. However, new opportunities emerged with the transition, which allowed women to use their political rights to secure more civil and social rights. (shrink)

During the past few years significant progress has been made in our understanding of the structure and function of the proteins involved in eukaryotic DNA replication. Data from several laboratories suggest that, in contrast to prokaryotic DNA replication, two distinct DNA polymerases are required for eukaryotic DNA replication, i.e. DNA polymerase delta for the synthesis of the leading strand and DNA polymerase alpha for the lagging strand. Several accessory proteins analogous to prokaryotic replication factors have been identified and some of (...) these are specific for pol delta whereas others affect both DNA replicases. The replicases and their accessory proteins appear to be highly conserved in eukaryotes, as homologous proteins have been found in species ranging from humans to yeast. (shrink)

Academia-intelligence agency collaborations are on the rise for a variety of reasons. These can take many forms, one of which is in the classroom, using students to stand in for intelligence analysts. Classrooms, however, are ethically complex spaces, with students considered vulnerable populations, and become even more complex when layering multiple goals, activities, tools, and stakeholders over those traditionally present. This does not necessarily mean one must shy away from academia-intelligence agency partnerships in classrooms, but that these must be conducted (...) carefully and reflexively. This paper hopes to contribute to this conversation by describing one purposeful classroom encounter that occurred between a professor, students, and intelligence practitioners in the fall of 2015 at North Carolina State University: an experiment conducted as part of a graduate-level political science class that involved students working with a prototype analytic technology, a type of participatory sensing/self-tracking device, developed by the National Security Agency. This experiment opened up the following questions that this paper will explore: What social, ethical, and pedagogical considerations arise with the deployment of a prototype intelligence technology in the college classroom, and how can they be addressed? How can academia-intelligence agency collaboration in the classroom be conducted in ways that provide benefits to all parties, while minimizing disruptions and negative consequences? This paper will discuss the experimental findings in the context of ethical perspectives involved in values in design and participatory/self-tracking data practices, and discuss lessons learned for the ethics of future academia-intelligence agency partnerships in the classroom. (shrink)

In this paper l examine the extent to which Locke’s reIigious and poIiticaI ideoIogy might be considered to exempIify values which have Ied to environmentaI deterioration. In the Two Treatises of Governlnent, Locke appears to hold a view of dominion which compromises humanitarian principles for economic gain. He often asserts that man has a right to accumulate property and to use land and animals for comfort and convenience. This right issues from God’s decree that men subdue the Earth and have (...) dominion over every living thing. Although abuse of the environment appears to be justified in Locke’s political works, I argue that there are many passages in this work that cast doubt on such an interpretation. Further, the view of dominion adopted in Locke's educational work is one of responsible stewardship. On the whole, his view stresses man’s duties and obligation towards all creation. (shrink)